产品货号：
Z28777
中文名称：
TNFR1/TNFRSF1A抗体
英文名称：
Anti-TNFR1/TNFRSF1A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TNFR1/TNFRSF1A Antibody |
| 指标别名 | CD120a;FPF;p55;p55 R;p60;TBP1;TBPI;TNF R;TNF R I;TNF R1;TNF R55;TNF Receptor 1;TNF Receptor I;TNF RI;TNFAR;TNFR I;TNFR1;TNFR55;TNFR60;TNFRSF1A |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC |
| 基因名称 | TNFRSF1A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human TNF Receptor I(195-211aa CLPQIENVKGTEDSGTT). |
| 实际分子量 | 55～60KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Tumor necrosis factor receptor 1(TNFR1),a potent cytokine,elicits a broad spectrum of biologic responses which are mediated by binding to a cell surface receptor.Its gene is located on 12p13.2.The coding region and the 3-prime untranslated region of TNFR1 are distributed over 10 exons.There are 2 different proteins that serve as major receptors for TNF-alpha,one associated with myeloid cells and one associated with epithelial cells.Additionally,TNFR1 associates with the MADD protein through a death domain-death domain interaction.MADD provides a physical link between TNFR1 and the induction of mitogen-activated protein(MAP) kinase(e.g.,ERK2) activation and arachidonic acid release.TNFR1-induced apoptosis involves 2 sequential signaling complexes.Complex I,the initial plasma membrane-bound complex,consists of TNFR1,the adaptor TRADD,the kinase RIP1,and TRAF2 and rapidly signals activation of NF-kappa-B.In a second step,TRADD and RIP1 associate with FADD and caspase-8,forming a cytoplasmic complex,complex II. |
| Uniprot ID | P19438 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | tumor necrosis factor receptor superfamily,member 1A |
| 蛋白名全称 | Tumor necrosis factor receptor superfamily member 1A |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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